Friends TV Show

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My wife got me the first six seasons of Friends for my birthday last month.

We’ve already watched out way through the first two seasons. We’re looking forward to the rest!

Initially she and I had both thought that Friends has only seven seasons. We were both pleasantly surprised to learn that the series has ten seasons! Three extra ones to look forward to!

My wife didn’t know about the Joey spin off either, so that’s one more season to look forward to.

Well, technically two Joey seasons, but the second was never released in the US and likely won’t be until the franchise is sold to someone. Who knows when that’ll happen!

Inevitably watching friends leads to comparisons between ourselves and the six characters.

I’ve always thought of myself like Chandler because I make a lot of jokes and I act like a little boy a lot.

My wife thinks I’m like Ross because I’m a nerdy scientist.

I think my wife is like Monica because she’s a perfectionist.

My wife thinks she’s like Rachel because she ends up with Ross and I am like Ross.

I took one of those quiz things to see which Friends character you are the other day. Here’s the Quiz Link.

I got Monica for some reason. I’m still a little confused by this.

It might’ve been because you can’t select more than one response. I personally would’ve put Monica as fifth on my list of which character I’m most like.

#1 Chandler, #2 Ross, #3 Phoebe, #4 Joey, #5 Monica, #6 Rachel

My wife got Monica on the test, so I am right!

-Mister Ed

Worms and Introns

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I have two jobs right now. One of them is an internship working on introns.

Introns are part of your genes, but they’re a strange part.

Imagine your genes are like a TV show. There are parts you watch and there are the commercials that you mute or ignore.

When the TV show comes out on DVD or Netflix the commercials are removed.

Genes are split up into watchable parts and commercials too. The watchable parts are called exons and the commercials are called introns.

When DNA makes RNA the introns are removed from the code, just like when a TV show is released on DVD the commercials are removed.

For a while scientists thought that introns did nothing for the genetic code of an organism. Introns were just useless DNA trash.

That changed in the late 1980s when some introns were found to enhance the expression of genes.

Some genes have what are called enhancing introns that increase the expression of that gene. This is called intron mediated enhancement (IME).

If you take an enhancing intron from one gene and put it into another, then the other gene will create more RNA and thus more proteins as well.

So enhancing introns increase expression of a gene, but not much is known about why. The lab I work in is one of the few that studies this process to try and figure out the specifics.

Most intron research right now is done in plants. I’m trying to extend that research to animals by using worms.

The worms I use are called C. elegans. They’re only 1mm long and are commonly used for research projects around the globe.

My lab previously discovered that enhancing introns in plants work best near the beginning of a gene.

My project is to see if the same holds true for C. elegans.

I’ll also be looking at whether an intron that is enhancing in plants is also enhancing when out into a gene in C. elegans.

That’s all for now!

-Mister Ed