Institute of Regenerative Cures

My class got to go on a field trip last week.

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All the joys of barely being able to see the tour guide when you’re at the back of the group.

I know! Field trips in a Master’s of Science program? How ridiculous!

It was awesome. We went to the Institute of Regenerative Cures in Sacramento.

I arrived early and waited out front with some classmates. Our tour guide arrived and we waited out front a little longer til everyone showed up.

While waiting the tour guide, who had designed the building we were about to go into, told us about his hobby, early television history!

After the primer on early television we entered the building and got a tour of one of the best facilities for practicing biology in existence right now.

The building itself was actually built a long time ago for the California state fair. It was the “women’s building.”

The brick exterior and columnaic entrance have stayed the same since the building was constructed to maintain the historical site. The interior has been heavily modified.

The building had no roof back in the day and was just an enclosure for a bunch of different events that you usually see at state fairs.

The building was sold to the University of California system. They slapped a roof on it, and used it to store records.

Our tour guide said that he was called in to turn it into a biology facility later on. Half the building is used for bio research while the other half is rented out to other companies.

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The entrance hallway with pictures of the cooler discoveries at the Institute.

The researchers in the Institute are working on a number of things. They researched a treatment for the “bubble boy disease” there. They’re working on using umbilical cords to create bone marrow for transplants, using Tal proteins to treat Huntington’s, creating HIV resistant cells, and helping people who can’t swallow to swallow are just a few of the things they work on there.

Where all the research is done!
Where all the research is done!

The tour guide also showed us the section that he was most proud of as he had designed it. A set of rooms for making the actual drugs and proteins to export to hospitals. Making the drugs requires extremely sterile technique to prevent giving someone who is already sick something that will make them worse. The rooms are designed to be extremely sterile.

To enter the rooms you pass through an airlock where you are required to cover every inch of your body in a disposable gown.

The airlock goes to a hallway with access to three separate clean rooms.

There is “negative pressure” in the rooms. That means that air is constantly entering the room from the top and going out the bottom. This is so that if any cells that are worked with in the rooms get into the air, they will be redirected to teh ground and sucked out through a grate in the wall instead of ending up in someone’s medicine.

The air is cleaned excessively to about 3000 times more clean than average air before entering the facility.

There is a lot of electrical equipment in the rooms that will require replacing eventually. To prevent electricians from having to gown up just to replace a lightbulb, all the eletricals are accessible from panels on the second story of the building.

It was pretty cool for a scientist like me to see the best possible place to do research in. The tour guide mentioned that he does tours of the interior of the super clean rooms for smaller groups. I might take him up on that at a later time!

-GoCorral

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Disposing of GMOs

The rice we grow in one of my lab's greenhouses.
The rice we grow in one of my lab’s greenhouses.

Yesterday I was working out at the greenhouse for my rice genetics lab.

I was getting rid of some old rice plants that we’d collected the seed from and no longer needed.

If a plant got to this point in a garden you’d normally throw it in the compost so it would be useful next year.

That’s not allowed for the rice we work with in my lab because it is an untested transgenic line.

Some members of the public dislike altering the genetics of food crops to create genetically modified organisms (GMOs). There are a couple of logical reasons for this and a couple of illogical ones.

Logical reasons include: religious objection, lack of crop diversification, cross-species allergens, and the strengthening of agribusiness monopolies that often accompanies GMO crop use.

Illogical reasons often have something to do with safety or not knowing what is in a product when you purchase it at the grocery store.

I could go on about this a lot. GMOs are a complex topic with a lot of ground to cover, but that wasn’t why I was writing this post today.

Because of the fear of GMOs, they need to go through extensive testing before they are declared legally safe. This testing can take up to ten years.

We don’t do that for every strain of modified rice in our lab, so certain precautions need to be taken.

Yesterday I cut off all the excess seeds on the old rice plants. The seeds go into a plastic bag.

The seed bag and the leftover portion you can see above both go into an orange dumpster at the center of the greenhouse complex.

All the stuff in the orange dumpster then goes into a special oven that ensures the modified crops won’t somehow get into the wild and start growing there.

After the special oven, called an autoclave, has destroyed the genetic material in the rice it can go into a normal dumpster or be used for compost.

Just another little glimpse at my job!

-Mister Ed